64 research outputs found

    A Survey of Different Dos Attacks on Wireless Network

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    Wireless technologies like Wireless LAN (WLAN) 802.11 picking up ubiquity in all associations, undertakings and colleges because of its profitability, cost sparing when contrasted with wired system and usability by enabling the system clients to move physically while keeping up an association with the wireless system. Wireless systems are main stream among the Laptop client group today in light of the portability and usability. Individuals working through remote association must know about the surroundings because of the different sorts of assaults made by the interlopers. Remote systems are extremely defenseless against (Denial of Service) DoS attacks. DoS attacks are an endeavor to make a machine or system asset inaccessible to its clients. It can happen in numerous layers of OSI demonstrate and can happen in different frame Network clients can ensure their frameworks with Wi-Fi Protected Access (WPA) security conventions and Wired Equivalent Privacy (WEP), however DoS attack still can't be averted utilizing these conventions. These attacks bring about debasement of the system quality or finish loss of accessibility of the system inside the association. This survey paper makes a review on various kinds of DoS attacks and their countermeasures on the framework systems which depend on the Access Points (AP). The fundamental assaults called Deauthentication and Disassociation Flooding. DoS assaults are considered there avoidance/discovery arrangements. Keywords- Access Points, DoS, Wireless Security, 802.11, Disassociation, Deauthentication, Flooding attack

    Provisions & Issues Relating to Bail Laws In India

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    The primary object, to hold and arrest a person accused, is to ensure that his / her appearance is at the time of trial and to ensure that in case he/she is convicted guilty he is available to receive the result. The common question is that if the presence of the accused before the court of law could reasonably be ensured without captivating him, it would be unjust and unfair to deprive the accused of his liberty during the pendency of the criminal proceedings against him. The release on the lease is very important to an accused because the result of pre-trial detention is itself very critical as the accused will be subjected to the psychological and physical deprivation of jail life, the accused will lose his / her job, and prevents him from contributing effectively to the preparation of his defense and most importantly the burden of detention often falls on the innocent members of his family. The article briefly tries to discuss the impact of the law in India on its poor subjects, by briefly emphasizing the history of the lease system to the current prevailing practice in India

    A CLINICAL EVALUATION OF ANTIMICROBIAL ACTIVITY OF GOMUTRA ARKA IN DUSTA VRANA

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    Vrana chikitsha is very significant in field of Shalya tantra. Healing of Vrana is depends on many factors. Among them growth of microorganism play essential role to slow the process of healing. In Dusta Vrana to improve the healthy granulation and to reduce the colony count of microorganism specific Krimghna dravya is required for that in Shasthi upkrama under Krimighna karma Gomutra Arka is advised. Which has additional property of Lekhana and Ropana. Gomutra Arka is given importance in many oral classical formulation of Ayurveda to treat the Krimi, which is not evaluated for local application on Dusta Vrana yet. Materials and Methods: A simple randomized controlled clinical study where 50 patients were equally divided as group A: Gomutra Arka (trial drug) and Group B: Povidone-iodine (standard drug) for 14 days. Observations and results: The study result revealed that Gomutra Arka proved to be better Antimicrobial agents than povidone-iodine with a highly significant p-value of 0.04 in comparison to 0.68. It was also established in the study that 10mlGomutra Arka proved to be more effective on different microorganisms that are Staphylococcus Aureus, Pseudomonas Aeruginosa, Shigella, Salmonella, E. Coli, and Candida Albicans. Conclusion: The Gomutra Arka acts as an antimicrobial agent due to its property like Katu tikta kashya rasa which are Krimighna in nature by this inhibition of microorganism could happen also due to the Ushna tikshna and Kshara guna gives unfavorable environment for bacterial growth. The presence of constituents like copper, aurum, urea, ammonia further helps in antimicrobial activity. Therefore, Gomutra Arka can be used in regular practice as its available at a low cost, affordable and the study proves its efficiency over the Povidone-iodine controlled group

    Study of vertical transmission of COVID-19 infection in COVID-19 positive obstetrical patients by comparing amniotic fluid and immediate neonatal COVID-19 RT-PCR

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    Background: The objective of this study was to estimate the incidence of vertical transmission COVID-19 by RT-PCR.Methods: In this hospital based prospective study, all COVID-19 positive pregnant women admitted in COVID ward in Muzaffarnagar medical college and hospital from April 2020 to January 2021 were included. A detailed history and examination was done and all routine investigations were done as per protocol. Samples were taken from amniotic fluid during vaginal delivery or caesarean section and collected in viral transport medium. Sample were also collected as nasal and oropharyngeal swab from neonate immediately after birth and sent for COVID 19 RT-PCR.Results: Out of total 50 cases; 43 (86%) neonates were delivered via LSCS and 7 (14%) by normal delivery, out of these 41 (82%) neonates were normal; 4 (8%) were IUGR, 2 (4%) were IUD, 2 (4%) were pre-term and 1 (2%) neonatal death. All 50 amniotic fluid as well as nasal and oropharyngeal samples of all neonates were negative by RT-PCR.Conclusions: Low vertical transmission may be due to the fact that antibodies are produced by mother that crosses the placenta and saves the fetus or there are highly specific immunological mediators in the placenta that do not allow the infection to pass to the fetus

    Hydrothermally tailored three-dimensional Ni-V layered double hydroxide nanosheets as high-performance hybrid supercapacitor applications

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    Here, we report a facile and easily scalable hydrothermal synthetic strategy to synthesize Ni–V layered double hydroxide applications. NiV LDH nanosheets with varying Ni-to-V ratios were prepared. Three-dimensional curved nanosheets of Ni0.80V0.20 LDH showed better electrochemical performance compared to other synthesized NiV LDHs. The electrode coated with Ni0.80V0.20 LDH nanosheets in a three-electrode cell configuration showed excellent pseudocapacitive behavior, having a high specific capacity of 711 C g–1 (1581 F g–1) at a current density of 1 A g–1 in 2 M KOH. The material showed an excellent rate capability and retained the high specific capacity of 549 C g–1 (1220 F g–1) at a current density of 10 A g–1 and low internal resistances. Owing to its superior performance, Ni0.80V0.20 LDH nanosheets were used as positive electrode and commercial activated carbon was used as negative electrode for constructing a hybrid supercapacitor (HSC) device, having a working voltage of 1.5 V. The HSC device exhibited a high specific capacitance of 98 F g–1 at a current density of 1 A g–1. The HSC device showed a higher energy density of 30.6 Wh kg–1 at a power density of 0.78 kW kg–1 and maintained a high value of 24 Wh kg–1 when the power density was increased to 11.1 kW kg–1. The performance of NiV LDHs nanosheets indicates their great potential as low-cost electrode material for future energy-storage device

    Comparative Evaluation of Two Different Marketed Brands of Enalapril maleate

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    Efficacy of pharmaceuticals dosage form generally depends on their formulation properties and manufacturing methods, hence it is likely that the quality of dosage form may vary. Renin acts on angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin-converting enzyme (ACE). Angiotensin II, a potent vasoconstrictor increases blood pressure by increasing vasopressin production and aldosterone secretion. Enalaprilat, the active metabolite of enalapril, inhibits ACE, hence decreases levels of angiotensin II resulting in less vasoconstriction and decreased blood pressure. The study was exclusively experimental that used IP and other standard books to check in vitro quality of enalapril maleate tablet using different analytical techniques and procedure. Test for weight variation, hardness, friability, disintegration time, and dissolution were conducted. The dissolution test was performed at pH 6.8 for both the brands of the tablet. Further all the tablets passed weight variation, hardness, friability and disintegration test as per the pharmacopoeial standard. Hence we can conclude that both the brands of tablets are equal and both the brands contain equal quantity of active pharmaceutical ingredient (API). Both the brands having higher and lower costs exert similar action. Keywords: Enalapril maleate, In Vitro, Dissolution test, Enalapri

    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

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    In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

    A comparative study of honey, jaggery an ethanol as cytological fixatives

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    The processing of cytological samples. It is the gold standard cytological fixative used in many laboratories. However, it is an expensive, volatile and flammable liquid with an irritant smell. It has also been shown to be carcinogenic in some animal models. Hence, a need to identify a safer substitute of alcohol cytological fixative is necessary. The aim of study was to analyse the efficacy of cytological smears fixed in ethanol & 20% unprocessed honey and 30% jaggery solution and to compare the efficacy between the three fixatives on staining. Three buccal smears from 50 healthy volunteers each, were collected from either cheek or tongue using wooden spatula. One of the smear was fixed in ethanol (95%) and Rapid Papanicolaou staining was done. And the other two smear was fixed in honey (20%) and Jaggery (30%) and Rapid Papanicolaou staining was done. The cytoplasmic and nuclear details were evaluated using following parameters:- nuclear staining, cytoplasmic staining, cell morphology, clarity of staining and uniformity of staining. The results were recorded by 2 independent oral pathologists.  Pearson Chi square test and Bonferroni post hoc test were used for comparison of qualitative data.&nbsp

    Usage of coconut oil as a biofriendly xylene substitute in tissue processing and staining

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    Background: Xylene is colorless flammable liquids that is extensively used in stock pathology, however it is carcinogenic & neurotoxic. Hence, need to identify safer substitute of xylene is necessary. Aim: The aim of study was to determine efficacy of Coconut oil as a biofriendly substitute for Xylene as a clearing and dewaxing agent. Materials and methods: 70 soft tissue specimens were divided into equal halves which were processed simultaneously in xylene and coconut oil as clearing agents. Samples obtained after processing were observed for following parameters:- Rigidity, Tissue shrinkage and Translucency. Paraffin blocks were prepared and two serial sections were obtained from each block. During sectioning tissue samples were observed for Nicks and Ribbons. After sectioning, one section was stained by standard hematoxylin and eosin using xylene while other section was stained by standard hematoxylin and eosin using Coconut oil as dewaxing and clearing agent. Tissue were evaluated using following parameters:- cytoplasmic staining, Nuclear staining, Uniformity of staining, Clarity of staining, Crispness of staining and cell morphology criteria by 3 independent oral pathologists. Kappa test and Chi-square test were done
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